Symptoms of Klippel-Trenaunay Syndrome

Klippel-Trenaunay Syndrome pic
Klippel-Trenaunay Syndrome

As a surgeon at Western Vascular Institute, Dr. Mitar Vranic draws on almost two decades of specialized experience. Over this time, Dr. Mitar Vranic has provided care to individuals with Klippel-Trenaunay syndrome.

A rare genetic condition, Klippel-Trenaunay syndrome is characterized by abnormal growth of blood vessels, bone, and soft tissue. The majority of patients with the syndrome present at birth with a red-purple birthmark, which typically appears on a leg and stems from the swelling of small vessels near the skin’s surface. In some patients, the birthmark develops small blisters that are prone to bleeding.

Vascular abnormalities caused by the syndrome may also include varicose veins, which most often form on the legs and close to the skin’s surface. Some patients do develop varicosity of the deeper leg veins, a complication that can lead to a variety of blood clot known as deep vein thrombosis. These clots are particularly dangerous as they can dislodge from the leg and travel through the bloodstream to the lungs, where they can result in pulmonary embolism.

Patients with Klippel-Trenaunay syndrome are also prone to excessive growth of the soft tissues and bones. This growth typically affects only one leg, though some patients experience the same issue in the arms and occasionally in the torso. Symptoms include pain, a feeling of heaviness, and restricted movement, as well as potential uneven leg growth that can inhibit comfortable walking.